Aza-Peterson Olefinations: Rapid Synthesis of (E)-Alkenes

Stereoselective synthesis of Z-alkenes.

This chapter offers a general review of the evolvement of methods for the stereoselective synthesis of Z-alkenes, with a focus on the development of catalytic systems towards this goal in recent years.

Organocatalytic synthesis of polysubstituted tetrahydrofurans from alkenes†

A novel, organocatalytic and environmentally friendly protocol for the synthesis of polysubstituted tetrahydrofurans from trivial starting materials has been described. By employing 2,2,2-trifluoroacetophenone-mediated oxidation, which utilizes H2O2 as a green oxidant, we introduce a sustainable procedure that embraces the principles of green chemistry for the production of substituted tetrahyd...

The Rectangularity Law of Transformers by E. L. Peterson

Synthesis of tetrasubstituted alkenes via metathesis.

Fully substituted olefin generation via metathesis is presented. Catalyst development, optimization of reaction conditions and substrate screening are included. In addition, asymmetric alkene metathesis, the cross metathesis reaction for this transformation and its application in natural products will be discussed.

Stereospecific hydrodehalogenation of alkenyl bromides: a new approach to the synthesis of (E)-alkenes.

The pair NaBH4-TMEDA and catalytic PdCl2(PPh3)2 in THF at room temperature is a mild and efficient system for the hydrodebromination of alkenyl bromides, providing a facile reduction procedure that allows completing the process advantageously, leading from aldehydes to (E)-alkenes.